St. Louis is an independent city on the eastern border of Missouri, United States, and is the second-largest city in the state. With a population of 318,069 in July 2011, it was the 58th-largest U.S. city at the 2010 U.S. Census. The Metropolitan Statistical Area (MSA population of 2,812,896 is the 18th-largest in the country. The Greater St. Louis combined statistical areas (CSA) population of 2,882,932 is the 15th-largest CSA in the country, the fourth-largest in the Midwest.

The Greater St. Louis area is the largest metropolitan area in Missouri. As of 2011, the St. Louis area is home to nine Fortune 500 companies, including:

  • Express Scripts
  • Emerson Electric
  • Monsanto, Reinsurance Group of America
  • Ameren
  • Charter Communication
  • Peabody Energy
  • Graybar Electric
  • Centene

Other notable corporations from the area include:

  • Cassidy TurleyEdward Jones Investments
  • AT&T Communications
  • Scottrade
  • Wells Fargo Advisors
  • Energizer Holdings
  • Furniture Brand International
  • Kerry Group
  • Post Holdings, Inc.
  • United Van Lines and Mayflower Transit
  • Ralcorp
  • Hardees
  • Enterprise Holdings

Health care and biotechnology institutions with operations in St. Louis include:

  • Pfizer the Donald Danforth Plant Science Center
  • Solae Company
  • Sigma-Aldrich
  • Multidata Systems International